Protein Details: Protein orai-2

Protein ID

ICDB_Pro_1212

Protein Name

Protein orai-2

Gene Name

Orai2; Tmem142b

Organism

Mus musculus (Mouse)

Length

250 amino acids

AlphaFoldDB

AF-Q8BH10-F1-model_v4.pdb

Function

Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor; STIM1.

Sequence

MSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1126/science.1112014; 10.1101/gr.2596504

RefSeq

NP_848866.2; XP_006504493.1; XP_006504494.1